Complement factor B (CFB) Monoclonal Antibody
- SKU:
- CAB21793
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Complement factor B (CFB) Monoclonal Antibody |
| Product Code: | CAB21793 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54100 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:10000-1:150000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Human plasma |
| Cellular Location: | Secreted |
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human Complement factor B (CFB) (NP_001701.2). |
| Sequence: | TVIDE IRDLL YIGKD RKNPR EDYLD VYVFG VGPLV NQVNI NALAS KKDNE QHVFK VKDME NLEDV FYQMI DESQS LSLCG MVWEH RKGTD YHKQP WQAKI S |
| Synonyms: | BF, FB, BFD, GBG, CFAB, CFBD, PBF2, AHUS4, FBI12, H2-Bf, ARMD14 |
| Calculated MW: | 86kDa |
| Observed MW: | 100kDa |
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