Complement C3 Monoclonal Antibody
- SKU:
- CAB22265
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Complement C3 Monoclonal Antibody |
| Product Code: | CAB22265 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC56851 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse liver, Rat liver, Rat lung |
| Cellular Location: | Cell surface, Extracellular region, Extracellular space, Plasma membrane |
This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1364-1663 of mouse Complement C3 (NP_033908.2). |
| Sequence: | RVSIR PAPET AKKPE EAKNT MFLEI CTKYL GDVDA TMSIL DISMM TGFAP DTKDL ELLAS GVDRY ISKYE MNKAF SNKNT LIIYL EKISH TEEDC LTFKV HQYFN VGLIQ PGSVK VYSYY NLEES CTRFY HPEKD DGMLS KLCHS EMCRC AEENC FMQQS QEKIN LNVRL DKACE PGVDY VYKTE LTNIE LLDDF DEYTM TIQQV IKSGS DEVQA GQQRK FISHI KCRNA LKLQK GKKYL MWGLS SDLWG EKPNT SYIIG KDTWV EHWPE AEECQ DQKYQ KQCEE LGAFT ESMVV YGCPN |
| Synonyms: | ASP, Plp, HSE-MSF |
| Calculated MW: | 186kDa |
| Observed MW: | 115kDa/187kDa |
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