COMP Monoclonal Antibody
- SKU:
- CAB22260
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | COMP Monoclonal Antibody |
| Product Code: | CAB22260 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54617 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HCT116, HepG2, Mouse testis, Rat testis |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human COMP (NP_000086.2). |
| Sequence: | ELLRQ QVREI TFLKN TVMEC DACGM QQSVR TGLPS VRPLL HCAPG FCFPG VACIQ TESGA RCGPC PAGFT GNGSH CTDVN ECNAH PCFPR VRCIN TSPGF R |
| Synonyms: | MED, CTS2, EDM1, EPD1, TSP5, PSACH, THBS5, TSP-5 |
| Calculated MW: | 83kDa |
| Observed MW: | 100kDa |
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