COMMD6 Antibody (PACO37382)
- SKU:
- PACO37382
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | COMMD6 Antibody (PACO37382) |
| Antibody SKU: | PACO37382 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human COMM domain-containing protein 6 protein (1-85AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO37382 at dilution of 1:100. |
| Background: | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. |
| Synonyms: | COMM domain-containing protein 6, COMMD6 |
| UniProt Protein Function: | COMMD6: Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q22Cellular Component: cytoplasm; nucleusMolecular Function: NF-kappaB binding; protein bindingBiological Process: transcription, DNA-dependent; inhibition of NF-kappaB transcription factor |
| UniProt Protein Details: | |
| NCBI Summary: | COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009] |
| UniProt Code: | Q7Z4G1 |
| NCBI GenInfo Identifier: | 565671780 |
| NCBI Gene ID: | 170622 |
| NCBI Accession: | NP_001274323.1 |
| UniProt Secondary Accession: | Q7Z4G1,Q5TBK4, A6NF28, B7ZLN0 |
| UniProt Related Accession: | Q7Z4G1 |
| Molecular Weight: | 10,908 Da |
| NCBI Full Name: | COMM domain-containing protein 6 isoform c |
| NCBI Synonym Full Names: | COMM domain containing 6 |
| NCBI Official Symbol: | COMMD6 |
| NCBI Official Synonym Symbols: | Acrg |
| NCBI Protein Information: | COMM domain-containing protein 6; Acrg embryonic lethality minimal region ortholog |
| UniProt Protein Name: | COMM domain-containing protein 6 |
| UniProt Synonym Protein Names: | |
| Protein Family: | COMM domain-containing protein |
| UniProt Gene Name: | COMMD6 |
| UniProt Entry Name: | COMD6_HUMAN |
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