Collagen IV Monoclonal Antibody

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SKU:
CAB24008
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:Collagen IV Monoclonal Antibody
Product Code:CAB24008
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC62585
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA, DB
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000, DB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa
Cellular Location:Secreted

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1573-1690 of human COL4A4（NP_000083.3）.
Sequence:AQAVA VHSQD QSIPP CPQTW RSLWI GYSFL MHTGA GDQGG GQALM SPGSC LEDFR AAPFL ECQGR QGTCH FFANK YSFWL TTVKA DLQFS SAPAP DTLKE SQAQR QKISR CQVCV KYS
Synonyms:BFH, ATS2, BFH1, CA44
Calculated MW:164kDa
Observed MW:170-185kDa
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