Collagen I/COL1A2 Monoclonal Antibody (CAB22349)
- SKU:
- CAB22349
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Collagen I/COL1A2 Monoclonal Antibody |
| Product Code: | CAB22349 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52125 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U-138MG |
| Cellular Location: | Secreted, Extracellular matrix, Extracellular space |
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human Collagen I/COL1A2 (NP_000080.2). |
| Sequence: | PTGDP GKNGD KGHAG LAGAR GAPGP DGNNG AQGPP GPQGV QGGKG EQGPP GPPGF QGLPG PSGPA GEVGK PGERG LHGEF GLPGP AGPRG ERGPP GESGA A |
| Synonyms: | OI4, EDSCV, EDSARTH2 |
| Calculated MW: | 129kDa |
| Observed MW: | 165kDa |
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