Collagen I/COL1A1 Monoclonal Antibody (CAB22090)
- SKU:
- CAB22090
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | Collagen I/COL1A1 Monoclonal Antibody |
| Product Code: | CAB22090 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53610 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:100-1:500, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | NIH/3T3 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1151-1250 of human Collagen I/COL1A1 (NP_000079.2). |
| Sequence: | GKDGL NGLPG PIGPP GPRGR TGDAG PVGPP GPPGP PGPPG PPSAG FDFSF LPQPP QEKAH DGGRY YRADD ANVVR DRDLE VDTTL KSLSQ QIENI RSPEG |
| Synonyms: | OI1, OI2, OI3, OI4, EDSC, CAFYD, EDSARTH1 |
| Calculated MW: | 139kDa |
| Observed MW: | 220kDa |
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