COL25A1 Antibody (PACO05524)
- SKU:
- PACO05524
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | COL25A1 Antibody (PACO05524) |
| Antibody SKU: | PACO05524 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from the Internal region of human COL25A1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | COL25A1; Collagen α-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P |
| UniProt Protein Function: | COL25A1: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4q25Cellular Component: extracellular space; collagen; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane; extracellular regionMolecular Function: heparin binding; beta-amyloid bindingBiological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesisDisease: Fibrosis Of Extraocular Muscles, Congenital, 5 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9BXS0 |
| NCBI GenInfo Identifier: | 38570075 |
| NCBI Gene ID: | 84570 |
| NCBI Accession: | NP_942014.1 |
| UniProt Secondary Accession: | Q9BXS0,Q9BXR9, A8MPZ6 |
| UniProt Related Accession: | Q9BXS0 |
| Molecular Weight: | 64,771 Da |
| NCBI Full Name: | collagen alpha-1(XXV) chain isoform 1 |
| NCBI Synonym Full Names: | collagen, type XXV, alpha 1 |
| NCBI Official Symbol: | COL25A1 |
| NCBI Official Synonym Symbols: | AMY; CLAC; CLACP; CLAC-P |
| NCBI Protein Information: | collagen alpha-1(XXV) chain; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component |
| UniProt Protein Name: | Collagen alpha-1(XXV) chain |
| UniProt Synonym Protein Names: | Alzheimer disease amyloid-associated protein; AMY; CLAC-P |
| Protein Family: | Ribonuclease clavin |
| UniProt Gene Name: | COL25A1 |
| UniProt Entry Name: | COPA1_HUMAN |
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