Cobra venom factor Antibody (PACO50934)
- SKU:
- PACO50934
- Product Type:
- Antibody
- Reactivity:
- Snake
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Cobra venom factor Antibody (PACO50934) |
| Antibody SKU: | PACO50934 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Naja kaouthia |
| Immunogen: | Recombinant Naja kaouthia Cobra venom factor protein (733-984AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: Cobra venom factor antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. predicted band size: 45 kDa. observed band size: 45 kDa.. |
| Background: | Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. |
| Synonyms: | Cobra venom factor (CVF) (CVFk) (Complement C3 homolog) [Cleaved into: Cobra venom factor α chain; Cobra venom factor γ chain; Cobra venom factor β chain] |
| UniProt Protein Function: | Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q91132 |
| NCBI GenInfo Identifier: | 54035743 |
| NCBI Gene ID: | |
| NCBI Accession: | Q91132.1 |
| UniProt Secondary Accession: | Q91132,Q6PQH3, Q6RHR7 |
| UniProt Related Accession: | Q91132 |
| Molecular Weight: | 44.4 kDa |
| NCBI Full Name: | Cobra venom factor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Cobra venom factor |
| UniProt Synonym Protein Names: | Complement C3 homolog |
| Protein Family: | Cobra venom factor |
| UniProt Gene Name: | CVF |
| UniProt Entry Name: | VCO3_NAJKA |
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