CNOT9 Antibody (PACO38898)
- SKU:
- PACO38898
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CNOT9 Antibody (PACO38898) |
| Antibody SKU: | PACO38898 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human CCR4-NOT transcription complex subunit 9 protein (1-258AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CNOT9 antibody at 6µg/ml. Lane 1: HepG2 whole cell lysate. Lane 2: Mouse small intestine tissue. Lane 3: Mouse spleen tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 34, 37, 30 kDa. Observed band size: 34 kDa. |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO38898 at dilution of 1:100. |
| Background: | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. |
| Synonyms: | CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1), CNOT9, RCD1 RQCD1 |
| UniProt Protein Function: | RQCD1: Transcription factor that down-regulates MYB- and JUN- dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. Belongs to the RCD1 family.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 2q35Cellular Component: CCR4-NOT complex; cytosol; membraneMolecular Function: protein binding; protein domain specific binding; protein homodimerization activityBiological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of estrogen receptor signaling pathway; negative regulation of translation; poly(A) tail shortening; sex differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q92600 |
| NCBI GenInfo Identifier: | 74716599 |
| NCBI Gene ID: | 9125 |
| NCBI Accession: | Q92600.1 |
| UniProt Secondary Accession: | Q92600,Q96IX4, B2RPI0, B5MDQ4, B7Z1E5 |
| UniProt Related Accession: | Q92600 |
| Molecular Weight: | 29,140 Da |
| NCBI Full Name: | Cell differentiation protein RCD1 homolog |
| NCBI Synonym Full Names: | CCR4-NOT transcription complex subunit 9 |
| NCBI Official Symbol: | CNOT9 |
| NCBI Official Synonym Symbols: | RCD1; CAF40; CT129; RCD-1; RQCD1 |
| NCBI Protein Information: | cell differentiation protein RCD1 homolog |
| UniProt Protein Name: | Cell differentiation protein RCD1 homolog |
| UniProt Synonym Protein Names: | CCR4-NOT transcription complex subunit 9 |
| Protein Family: | Cell differentiation protein |
| UniProt Gene Name: | RQCD1 |
| UniProt Entry Name: | RCD1_HUMAN |
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