CNOT4 Antibody (PACO04455)
- SKU:
- PACO04455
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CNOT4 Antibody |
| Antibody SKU: | PACO04455 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human CNOT4. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CNOT4; NOT4; CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp |
| UniProt Protein Function: | CNOT4: Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex. 8 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin ligaseChromosomal Location of Human Ortholog: 7q33Cellular Component: CCR4-NOT complex; cytosolMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; poly(A) tail shortening; protein autoubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] |
| UniProt Code: | O95628 |
| NCBI GenInfo Identifier: | 115502372 |
| NCBI Gene ID: | 4850 |
| NCBI Accession: | O95628.3 |
| UniProt Secondary Accession: | O95628,O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6 B7Z6I4, E7ET38, F8VQP3 |
| UniProt Related Accession: | O95628 |
| Molecular Weight: | 78,257 Da |
| NCBI Full Name: | CCR4-NOT transcription complex subunit 4 |
| NCBI Synonym Full Names: | CCR4-NOT transcription complex subunit 4 |
| NCBI Official Symbol: | CNOT4 |
| NCBI Official Synonym Symbols: | NOT4; NOT4H; CLONE243 |
| NCBI Protein Information: | CCR4-NOT transcription complex subunit 4 |
| UniProt Protein Name: | CCR4-NOT transcription complex subunit 4 |
| UniProt Synonym Protein Names: | CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp |
| Protein Family: | CCR4-NOT transcription complex |
| UniProt Gene Name: | CNOT4 |
| UniProt Entry Name: | CNOT4_HUMAN |
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