| UniProt Protein Function: | calponin 2: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoskeleton; focal adhesion; intercellular junction; membrane; stress fiber Biological Process: cytoskeleton organization and biogenesis; regulation of actin filament-based process |
| NCBI Summary: | The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q99439 |
| NCBI GenInfo Identifier: | 6226844 |
| NCBI Gene ID: | 1265 |
| NCBI Accession: | Q99439.4 |
| UniProt Secondary Accession: | Q99439,Q92578, A5D8U8, A6NFI4, D6W5X9, |
| UniProt Related Accession: | Q99439 |
| Molecular Weight: | 29,500 Da |
| NCBI Full Name: | Calponin-2 |
| NCBI Synonym Full Names: | calponin 2 |
| NCBI Official Symbol: | CNN2 |
| NCBI Protein Information: | calponin-2 |
| UniProt Protein Name: | Calponin-2 |
| UniProt Synonym Protein Names: | Calponin H2, smooth muscle; Neutral calponin |
| Protein Family: | Calponin |
| UniProt Gene Name: | CNN2 |
| UniProt Entry Name: | CNN2_HUMAN |
