Description
Product Name: | CNMD Polyclonal Antibody |
Product Code: | CAB23878 |
Reactivity: | Human |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:1000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Positive Samples: | 293T |
Cellular Location: | Endomembrane system, Secreted, Single-pass membrane protein, extracellular matrix, extracellular space |
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen: | Recombinant protein of human CNMD. |
Sequence: | VHYTM SINGK LQDGS MEIDA GNNLE TFKMG SGAEE AIAVN DFQNG ITGIR FAGGE KCYIK AQVKA RIPEV GAVTK QSISS KLEGK IMPVK YEENS LIWVA VDQPV KDNSF LSSKV LELCG DLPIF WLKPT YPKEI QRERR EVVRK IVPTT TKRPH SGPRS NPGAG RLNNE TRPSV QEDSQ AFNPD NPYHQ QEGES MTFDP RLDHE GICCI ECRRS YTHCQ KICEP LGGYY PWPYN YQGCR SACRV IMPCS WWVAR ILGMV |
Synonyms: | CHM1, CHM-I, LECT1, BRICD3, MYETS1 |
Calculated MW: | 37kDa |
Observed MW: | 42kDa |