CNIH2 Antibody (PACO36978)
- SKU:
- PACO36978
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CNIH2 Antibody (PACO36978) |
| Antibody SKU: | PACO36978 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Protein cornichon homolog 2 protein (94-138AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CNIH2 antibody at 2µg/ml. Lane 1: U251 whole cell lysate. Lane 2: Mouse liver tissue. Lane 3: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 19 kDa. Observed band size: 19 kDa. |
 | Immunofluorescent analysis of A549 cells using PACO36978 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO36978 at dilution of 1:100. |
| Background: | Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. |
| Synonyms: | Protein cornichon homolog 2 (CNIH-2) (Cornichon family AMPA receptor auxiliary protein 2) (Cornichon-like protein), CNIH2, CNIL |
| UniProt Protein Function: | CNIH2: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. Belongs to the cornichon family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 11q13.2Cellular Component: dendrite; dendritic shaft; dendritic spine; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; postsynaptic density; postsynaptic membraneMolecular Function: protein bindingBiological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q6PI25 |
| NCBI GenInfo Identifier: | 61563951 |
| NCBI Gene ID: | 254263 |
| NCBI Accession: | Q6PI25.1 |
| UniProt Secondary Accession: | Q6PI25 |
| UniProt Related Accession: | Q6PI25 |
| Molecular Weight: | 18,931 Da |
| NCBI Full Name: | Protein cornichon homolog 2 |
| NCBI Synonym Full Names: | cornichon family AMPA receptor auxiliary protein 2 |
| NCBI Official Symbol: | CNIH2 |
| NCBI Official Synonym Symbols: | Cnil; CNIH-2 |
| NCBI Protein Information: | protein cornichon homolog 2 |
| UniProt Protein Name: | Protein cornichon homolog 2 |
| UniProt Synonym Protein Names: | Cornichon family AMPA receptor auxiliary protein 2; Cornichon-like protein |
| Protein Family: | Protein cornichon |
| UniProt Gene Name: | CNIH2 |
| UniProt Entry Name: | CNIH2_HUMAN |
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