CNGA1 Antibody (PACO22261)
- SKU:
- PACO22261
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CNGA1 Antibody (PACO22261) |
| Antibody SKU: | PACO22261 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human CNGA1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HepG2 cells and K562 cells, using CNGA1 antibody. |
| Background: | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. |
| Synonyms: | cGMP-gated cation channel alpha 1; CNCG; CNCG1; CNG channel alpha 1; CNG-1 |
| UniProt Protein Function: | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
| UniProt Code: | P29973 |
| NCBI GenInfo Identifier: | 71143141 |
| NCBI Gene ID: | 1259 |
| NCBI Accession: | NP_000078.2 |
| UniProt Secondary Accession: | P29973,Q16279, Q16485, Q4W5E3, A8K7K6, J3KPZ2 |
| UniProt Related Accession: | P29973 |
| Molecular Weight: | 86,900 Da |
| NCBI Full Name: | cGMP-gated cation channel alpha-1 isoform 2 |
| NCBI Synonym Full Names: | cyclic nucleotide gated channel alpha 1 |
| NCBI Official Symbol: | CNGA1 |
| NCBI Official Synonym Symbols: | CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha |
| NCBI Protein Information: | cGMP-gated cation channel alpha-1 |
| UniProt Protein Name: | cGMP-gated cation channel alpha-1 |
| UniProt Synonym Protein Names: | Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha |
| Protein Family: | cGMP-gated cation channel |
| UniProt Gene Name: | CNGA1 |
| UniProt Entry Name: |
| Antibodies |
| CNGA1 Antibody (PACO02465) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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