Name: CNGA1 Antibody (PACO17710)
SKU: PACO17710
Availability: OutOfStock

Antibody Name:	CNGA1 Antibody (PACO17710)
Antibody SKU:	PACO17710
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human CNGA1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17710(CNGA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms:

cyclic nucleotide gated channel α 1

UniProt Protein Function:	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:	P29973
NCBI GenInfo Identifier:	71143141
NCBI Gene ID:	1259
NCBI Accession:	NP_000078.2
UniProt Secondary Accession:	P29973,Q16279, Q16485, Q4W5E3, A8K7K6, J3KPZ2
UniProt Related Accession:	P29973
Molecular Weight:	86,900 Da
NCBI Full Name:	cGMP-gated cation channel alpha-1 isoform 2
NCBI Synonym Full Names:	cyclic nucleotide gated channel alpha 1
NCBI Official Symbol:	CNGA1
NCBI Official Synonym Symbols:	CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha
NCBI Protein Information:	cGMP-gated cation channel alpha-1
UniProt Protein Name:	cGMP-gated cation channel alpha-1
UniProt Synonym Protein Names:	Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
Protein Family:	cGMP-gated cation channel
UniProt Gene Name:	CNGA1
UniProt Entry Name: