CMTM8 Antibody (PACO37646)
- SKU:
- PACO37646
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CMTM8 Antibody (PACO37646) |
| Antibody SKU: | PACO37646 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human CKLF-like MARVEL transmembrane domain-containing protein 8 protein (1-39AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO37646 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Synonyms: | CKLF-like MARVEL transmembrane domain-containing protein 8 (Chemokine-like factor superfamily member 8), CMTM8, CKLFSF8 |
| UniProt Protein Function: | CMTM8: a widely distributed protein with four transmembrane regions and a MARVEL domain. Associates with the epidermal growth factor receptor. Transfection into several cell lines suppresses EGF-induced cell proliferation and increases the rate of receptor endocytosis. The lack of EGFR-mediated signaling induces cells to undergo apoptosis via caspase-dependent and -independent pathways. Knockdown of CMTM8 by siRNA promotes cell proliferation and delayed EGFR endocytosis. Two splice-variant human isoforms have been reproted. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; extracellular space; integral to membrane; nucleoplasm Molecular Function:cytokine activity Biological Process: chemotaxis |
| NCBI Summary: | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q8IZV2 |
| NCBI GenInfo Identifier: | 145559454 |
| NCBI Gene ID: | 152189 |
| NCBI Accession: | Q8IZV2.2 |
| UniProt Secondary Accession: | Q8IZV2,Q8IW01, A5D6I7, |
| UniProt Related Accession: | Q8IZV2 |
| Molecular Weight: | 12,739 Da |
| NCBI Full Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| NCBI Synonym Full Names: | CKLF like MARVEL transmembrane domain containing 8 |
| NCBI Official Symbol: | CMTM8 |
| NCBI Official Synonym Symbols: | CKLFSF8; CKLFSF8-V2 |
| NCBI Protein Information: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Protein Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Synonym Protein Names: | Chemokine-like factor superfamily member 8 |
| Protein Family: | CKLF-like MARVEL transmembrane domain-containing protein |
| UniProt Gene Name: | CMTM8 |
| UniProt Entry Name: | CKLF8_HUMAN |
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