Name: CMTM8 Antibody (PACO17945)
SKU: PACO17945
Availability: OutOfStock

Antibody Name:	CMTM8 Antibody (PACO17945)
Antibody SKU:	PACO17945
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human CMTM8

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17945(CMTM8 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17945(CMTM8 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:	This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.
Synonyms:	CKLF-like MARVEL transmembrane domain containing 8

UniProt Protein Function:	CMTM8: a widely distributed protein with four transmembrane regions and a MARVEL domain. Associates with the epidermal growth factor receptor. Transfection into several cell lines suppresses EGF-induced cell proliferation and increases the rate of receptor endocytosis. The lack of EGFR-mediated signaling induces cells to undergo apoptosis via caspase-dependent and -independent pathways. Knockdown of CMTM8 by siRNA promotes cell proliferation and delayed EGFR endocytosis. Two splice-variant human isoforms have been reproted.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; extracellular space; integral to membrane; nucleoplasm Molecular Function:cytokine activity Biological Process: chemotaxis
NCBI Summary:	This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
UniProt Code:	Q8IZV2
NCBI GenInfo Identifier:	145559454
NCBI Gene ID:	152189
NCBI Accession:	Q8IZV2.2
UniProt Secondary Accession:	Q8IZV2,Q8IW01, A5D6I7,
UniProt Related Accession:	Q8IZV2
Molecular Weight:	12,739 Da
NCBI Full Name:	CKLF-like MARVEL transmembrane domain-containing protein 8
NCBI Synonym Full Names:	CKLF like MARVEL transmembrane domain containing 8
NCBI Official Symbol:	CMTM8
NCBI Official Synonym Symbols:	CKLFSF8; CKLFSF8-V2
NCBI Protein Information:	CKLF-like MARVEL transmembrane domain-containing protein 8
UniProt Protein Name:	CKLF-like MARVEL transmembrane domain-containing protein 8
UniProt Synonym Protein Names:	Chemokine-like factor superfamily member 8
Protein Family:	CKLF-like MARVEL transmembrane domain-containing protein
UniProt Gene Name:	CMTM8
UniProt Entry Name:	CKLF8_HUMAN