CMBL Antibody (PACO39282)
- SKU:
- PACO39282
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CMBL Antibody (PACO39282) |
| Antibody SKU: | PACO39282 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Carboxymethylenebutenolidase homolog protein (2-245AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CMBL antibody at 1µg/ml. Lane 1: Mouse kidney tissue. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 29 kDa. Observed band size: 29, 25 kDa. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO39282 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39282 at dilution of 1:100. |
| Background: | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. |
| Synonyms: | Carboxymethylenebutenolidase homolog (EC 3.1.-.-), CMBL |
| UniProt Protein Function: | CMBL: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Belongs to the dienelactone hydrolase family.Protein type: Hydrolase; EC 3.1.-.-Chromosomal Location of Human Ortholog: 5p15.2Cellular Component: cytosolMolecular Function: hydrolase activityBiological Process: xenobiotic metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010] |
| UniProt Code: | Q96DG6 |
| NCBI GenInfo Identifier: | 20270371 |
| NCBI Gene ID: | 134147 |
| NCBI Accession: | NP_620164.1 |
| UniProt Secondary Accession: | Q96DG6,Q8TED6, D3DTC7 |
| UniProt Related Accession: | Q96DG6 |
| Molecular Weight: | 28 kDa |
| NCBI Full Name: | carboxymethylenebutenolidase homolog |
| NCBI Synonym Full Names: | carboxymethylenebutenolidase homolog (Pseudomonas) |
| NCBI Official Symbol: | CMBL |
| NCBI Official Synonym Symbols: | JS-1 |
| NCBI Protein Information: | carboxymethylenebutenolidase homolog |
| UniProt Protein Name: | Carboxymethylenebutenolidase homolog |
| UniProt Synonym Protein Names: | |
| Protein Family: | Carboxymethylenebutenolidase |
| UniProt Gene Name: | CMBL |
| UniProt Entry Name: | CMBL_HUMAN |
| Antibodies |
| CMBL Antibody (PACO08478) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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