CLK4 Antibody (PACO21957)
- SKU:
- PACO21957
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CLK4 Antibody (PACO21957) |
| Antibody SKU: | PACO21957 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human CLK4. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HT-29 cells, using CLK4 antibody. |
| Background: | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. McNally T., Protein Sci. 12:1562-1566(2003). |
| Synonyms: | Dual specificity protein kinase CLK4; EC 2.7.12.1; CDC-like kinase 4; CLK4; |
| UniProt Protein Function: | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HAZ1 |
| NCBI GenInfo Identifier: | 10190706 |
| NCBI Gene ID: | 57396 |
| NCBI Accession: | NP_065717.1 |
| UniProt Secondary Accession: | Q9HAZ1 |
| UniProt Related Accession: | Q9HAZ1 |
| Molecular Weight: | 57,492 Da |
| NCBI Full Name: | dual specificity protein kinase CLK4 |
| NCBI Synonym Full Names: | CDC like kinase 4 |
| NCBI Official Symbol: | CLK4 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | dual specificity protein kinase CLK4 |
| UniProt Protein Name: | Dual specificity protein kinase CLK4 |
| UniProt Synonym Protein Names: | CDC-like kinase 4 |
| Protein Family: | CLK4-associating serine/arginine rich protein |
| UniProt Gene Name: | CLK4 |
| UniProt Entry Name: |
| Antibodies |
| CLK4 Antibody (PACO00613) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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