Description
Antibody Name: | CLIC2 Antibody (PACO25805) |
Antibody SKU: | PACO25805 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Chloride intracellular channel protein 2 protein (53-247AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO25805 at dilution of 1:100. | |
Western Blot Positive WB detected in: K562 whole cell lysate All lanes: CLIC2 antibody at 2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 29 kDa Observed band size: 29 kDa . | |
Immunofluorescent analysis of HepG2 cells using PACO25805 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. |
Synonyms: | Chloride intracellular channel protein 2 (XAP121), CLIC2 |
UniProt Protein Function: | CLIC2: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. Belongs to the chloride channel CLIC family.Protein type: Channel, chloride; Membrane protein, integralChromosomal Location of Human Ortholog: Xq28Cellular Component: cytoplasm; intracellular; nucleusMolecular Function: glutathione peroxidase activity; glutathione transferase activity; protein bindingBiological Process: glutathione metabolic process; positive regulation of binding; signal transduction; transportDisease: Mental Retardation, X-linked, Syndromic 32 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013] |
UniProt Code: | O15247 |
NCBI GenInfo Identifier: | 85681058 |
NCBI Gene ID: | 1193 |
NCBI Accession: | O15247.3 |
UniProt Secondary Accession: | O15247,O15174, Q5JT80, Q8TCE3, A8K9S0 |
UniProt Related Accession: | O15247 |
Molecular Weight: | 28,356 Da |
NCBI Full Name: | Chloride intracellular channel protein 2 |
NCBI Synonym Full Names: | chloride intracellular channel 2 |
NCBI Official Symbol: | CLIC2 |
NCBI Official Synonym Symbols: | CLIC2b; MRXS32; XAP121 |
NCBI Protein Information: | chloride intracellular channel protein 2 |
UniProt Protein Name: | Chloride intracellular channel protein 2 |
UniProt Synonym Protein Names: | XAP121 |
Protein Family: | Chloride intracellular channel protein |
UniProt Gene Name: | CLIC2 |
UniProt Entry Name: | CLIC2_HUMAN |