Antibody Name:	CLEC9A Antibody (PACO46642)
Antibody SKU:	PACO46642
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human C-type lectin domain family 9 member A protein (103-214AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot. All lanes: CLEC9A antibody IgG at 8µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 27 kDa. Observed band size: 27 kDa..
	Immunofluorescent analysis of MCF-7 cells using PACO46642 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Background:

Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Synonyms:

C-type lectin domain family 9 member A, CLEC9A

UniProt Protein Function:	CLEC9A: Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.2Cellular Component: cell surfaceBiological Process: positive regulation of cytokine secretion; receptor-mediated endocytosis
UniProt Protein Details:
NCBI Summary:	CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
UniProt Code:	Q6UXN8
NCBI GenInfo Identifier:	73917794
NCBI Gene ID:	283420
NCBI Accession:	Q6UXN8.1
UniProt Secondary Accession:	Q6UXN8,B0ZBM2
UniProt Related Accession:	Q6UXN8
Molecular Weight:	27,324 Da
NCBI Full Name:	C-type lectin domain family 9 member A
NCBI Synonym Full Names:	C-type lectin domain family 9 member A
NCBI Official Symbol:	CLEC9A
NCBI Official Synonym Symbols:	CD370; DNGR1; DNGR-1; UNQ9341
NCBI Protein Information:	C-type lectin domain family 9 member A
UniProt Protein Name:	C-type lectin domain family 9 member A
UniProt Synonym Protein Names:
Protein Family:	C-type lectin domain family
UniProt Gene Name:	CLEC9A
UniProt Entry Name:	CLC9A_HUMAN