Description
Antibody Name: | CLEC9A Antibody, HRP conjugated (PACO46643) |
Antibody SKU: | PACO46643 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human |
Immunogen: | Recombinant Human C-type lectin domain family 9 member A protein (103-214AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | HRP |
Background: | Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. |
Synonyms: | C-type lectin domain family 9 member A, CLEC9A |
UniProt Protein Function: | CLEC9A: Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.2Cellular Component: cell surfaceBiological Process: positive regulation of cytokine secretion; receptor-mediated endocytosis |
UniProt Protein Details: | |
NCBI Summary: | CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008] |
UniProt Code: | Q6UXN8 |
NCBI GenInfo Identifier: | 73917794 |
NCBI Gene ID: | 283420 |
NCBI Accession: | Q6UXN8.1 |
UniProt Secondary Accession: | Q6UXN8,B0ZBM2 |
UniProt Related Accession: | Q6UXN8 |
Molecular Weight: | 27,324 Da |
NCBI Full Name: | C-type lectin domain family 9 member A |
NCBI Synonym Full Names: | C-type lectin domain family 9 member A |
NCBI Official Symbol: | CLEC9A |
NCBI Official Synonym Symbols: | CD370; DNGR1; DNGR-1; UNQ9341 |
NCBI Protein Information: | C-type lectin domain family 9 member A |
UniProt Protein Name: | C-type lectin domain family 9 member A |
UniProt Synonym Protein Names: | |
Protein Family: | C-type lectin domain family |
UniProt Gene Name: | CLEC9A |
UniProt Entry Name: | CLC9A_HUMAN |