CLEC6A Antibody (PACO19556)
- SKU:
- PACO19556
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CLEC6A Antibody (PACO19556) |
| Antibody SKU: | PACO19556 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human CLEC6A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19556(CLEC6A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain |
| Synonyms: | C-type lectin domain family 6, member A |
| UniProt Protein Function: | dectin-2: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: plasma membraneMolecular Function: carbohydrate bindingBiological Process: defense response to fungus; innate immune response; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; stimulatory C-type lectin receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q6EIG7 |
| NCBI GenInfo Identifier: | 59797926 |
| NCBI Gene ID: | 93978 |
| NCBI Accession: | Q6EIG7.1 |
| UniProt Secondary Accession: | Q6EIG7,A2RUK3 |
| UniProt Related Accession: | Q6EIG7 |
| Molecular Weight: | 20,737 Da |
| NCBI Full Name: | C-type lectin domain family 6 member A |
| NCBI Synonym Full Names: | C-type lectin domain family 6 member A |
| NCBI Official Symbol: | CLEC6A |
| NCBI Official Synonym Symbols: | CLEC4N; CLECSF10 |
| NCBI Protein Information: | C-type lectin domain family 6 member A |
| UniProt Protein Name: | C-type lectin domain family 6 member A |
| UniProt Synonym Protein Names: | C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2 |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC6A |
| UniProt Entry Name: | CLC6A_HUMAN |
| Antibodies |
| CLEC6A Antibody (PACO07212) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Mouse CLEC6A/Dectin-2 Recombinant Protein (RPES3319)
system_update_altDatasheetMouse CLEC6A/Dectin-2 Recombinant Protein C-type lectin domain family 4 member N (CLEC4N), also known as Dectin-2, is a C-type lectin expressed by dendritic cells (DCs)
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost
eutC Antibody
Overview Product Name:eutC AntibodyProduct Code:PACO64709Size:50µLTarget Names:eutCSpecies Reactivity:Escherichia coli
EPHA10 Antibody
Overview Product Name:EPHA10 AntibodyProduct Code:PACO64693Size:50µLTarget Names:EPHA10Species Reactivity:HumanH