CLEC2A Antibody (PACO17707)
- SKU:
- PACO17707
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CLEC2A Antibody (PACO17707) |
| Antibody SKU: | PACO17707 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human CLEC2A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO17707(CLEC2A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17707(CLEC2A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors |
| Synonyms: | C-type lectin domain family 2, member A |
| UniProt Protein Function: | CLEC2A: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.31Cellular Component: integral to membrane; plasma membraneMolecular Function: protein binding; protein homodimerization activity; carbohydrate bindingBiological Process: natural killer cell mediated cytotoxicity |
| UniProt Protein Details: | |
| NCBI Summary: | CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008] |
| UniProt Code: | Q6UVW9 |
| NCBI GenInfo Identifier: | 212276429 |
| NCBI Gene ID: | 387836 |
| NCBI Accession: | Q6UVW9.2 |
| UniProt Secondary Accession: | Q6UVW9,A5Y4G5, A9QKS2, A9QKS3 |
| UniProt Related Accession: | Q6UVW9 |
| Molecular Weight: | 18,576 Da |
| NCBI Full Name: | C-type lectin domain family 2 member A |
| NCBI Synonym Full Names: | C-type lectin domain family 2, member A |
| NCBI Official Symbol: | CLEC2A |
| NCBI Official Synonym Symbols: | KACL; PILAR; UNQ5792; INPE5792 |
| NCBI Protein Information: | C-type lectin domain family 2 member A; keratinocyte-associated C-type lectin; proliferation-induced lymphocyte-associated receptor |
| UniProt Protein Name: | C-type lectin domain family 2 member A |
| UniProt Synonym Protein Names: | Keratinocyte-associated C-type lectin; KACL; Proliferation-induced lymphocyte-associated receptor; PILAR |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC2A |
| UniProt Entry Name: | CLC2A_HUMAN |
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