Cleaved PARP (Asp214) Polyclonal Antibody

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SKU:
CAB22535
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:Cleaved PARP (Asp214) Polyclonal Antibody
Product Code:CAB22535
Reactivity:Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:NIH/3T3+Staurosporine
Cellular Location:cytosol, mitochondrion, nuclear body, nuclear envelope, nuclear replication fork, nucleolus
Customer Validation:WB(Mus musculus)

Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1).

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 201-300 of Mouse PARP (Asp214) (NP_031441.2).
Sequence:AIKNE GKRKG DEVDG TDEVA KKKSK KGKDK DSSKL EKALK AQNEL IWNIK DELKK ACSTN DLKEL LIFNQ QQVPS GESAI LDRVA DGMAF GALLP CKECS
Synonyms:PARP, PPOL, ARTD1, Adprp, Adprt1, msPARP, parp-1, sPARP-1, 5830444G22Rik
Calculated MW:113kDa
Observed MW:89kDa
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