Cleaved Caspase-7 Monoclonal Antibody
- SKU:
- CAB23154
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Cleaved Caspase-7 Monoclonal Antibody |
| Product Code: | CAB23154 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC58776 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat |
| Cellular Location: | Cytoplasm |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CASP7 ( NP_001218.1). |
| Sequence: | CFRSL GFDVI VYNDC SCAKM QDLLK KASEE DHTNA ACFAC ILLSH GEENV IYGKD GVTPI KDLTA HFRGD RCKTL LEKPK LFFIQ ACRGT ELDDG IQADS G |
| Synonyms: | MCH3, CMH-1, LICE2, CASP-7, ICE-LAP3 |
| Calculated MW: | 34kDa |
| Observed MW: | 22kDa |
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