CLCN1 Monoclonal Antibody
- SKU:
- CAB21237
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | CLCN1 Monoclonal Antibody |
| Product Code: | CAB21237 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52491 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:20000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T |
| Cellular Location: | Membrane, Multi-pass membrane protein |
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 889-988 of human CLCN1 (NP_000074.3). |
| Sequence: | NTTST RKSTG APPSS AENWN LPEDR PGATG TGDVI AASPE TPVPS PSPEP PLSLA PGKVE GELEE LELVE SPGLE EELAD ILQGP SLRST DEEDE DELIL |
| Synonyms: | CLC1 |
| Calculated MW: | 109kDa |
| Observed MW: | 109kDa |
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