Claudin 6 Monoclonal Antibody
- SKU:
- CAB24011
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Claudin 6 Monoclonal Antibody |
| Product Code: | CAB24011 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC63026 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2, OVCAR-3, Mouse placenta, Rat kidney |
| Cellular Location: | apicolateral plasma membrane, bicellular tight junction, plasma membrane |
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 119-219 of human Claudin 6(NP_067018.2) |
| Sequence: | SGIVF VISGV LTLIP VCWTA HAIIR DFYNP LVAEA QKREL GASLY LGWAA SGLLL LGGGL LCCTC PSGGS QGPSH YMARY STSAP AISRG PSEYP TKNYV |
| Calculated MW: | 23kDa |
| Observed MW: | 22kDa |
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