Claudin-4 Monoclonal Antibody
- SKU:
- CAB23841
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | Claudin-4 Monoclonal Antibody |
| Product Code: | CAB23841 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC61052 |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000-1:8000, IHC-P 1:1000-1:3000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | MCF7, PC-3 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 109-209 of human CLDN4 (NP_690852.1) |
| Sequence: | EDESA KAKTM IVAGV VFLLA GLMVI VPVSW TAHNI IQDFY NPLVA SGQKR EMGAS LYVGW AASGL LLLGG GLLCC NCPPR TDKPY SAKYS AARSA AASNY V |
| Synonyms: | CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R, claudin-4 |
| Calculated MW: | 22kDa |
| Observed MW: | 18kDa |
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