Claudin 1 Monoclonal Antibody (CAB21971)
- SKU:
- CAB21971
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Claudin 1 Monoclonal Antibody |
| Product Code: | CAB21971 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54475 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:1000-1:5000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A-431, Hep G2, Mouse liver, Mouse kidney, Rat kidney |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| Customer Validation: | WB(Sus scrofa, Mus musculus, Anatinae, Coturnix japonica, Homo sapiens)IHC(Mus musculus) WB(Mus musculus)IF(Sus scrofa) IF(Mus musculus) |
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 112-211 of human Claudin 1 (NP_066924.1). |
| Sequence: | EVQKM RMAVI GGAIF LLAGL AILVA TAWYG NRIVQ EFYDP MTPVN ARYEF GQALF TGWAA ASLCL LGGAL LCCSC PRKTT SYPTP RPYPK PAPSS GKDYV |
| Synonyms: | CLD1, SEMP1, ILVASC |
| Calculated MW: | 23kDa |
| Observed MW: | 20kDa |
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