CIPC Antibody (PACO41582)
- SKU:
- PACO41582
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CIPC Antibody (PACO41582) |
| Antibody SKU: | PACO41582 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human CLOCK-interacting pacemaker protein (1-399AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CIPC antibody at 6µg/ml. Lane 1: A431 whole cell lysate. Lane 2: NIH/3T3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 43 kDa. Observed band size: 43 kDa. |
 | Immunohistochemistry of paraffin-embedded human stomach tissue using PACO41582 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO41582 at dilution of 1:100. |
| Background: | Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK. |
| Synonyms: | CLOCK-interacting pacemaker (CLOCK-interacting circadian protein), CIPC, KIAA1737 |
| UniProt Protein Function: | CIPC: Transcriptional repressor which acts as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimerChromosomal Location of Human Ortholog: 14q24.3Cellular Component: nucleusMolecular Function: protein bindingBiological Process: negative regulation of circadian rhythm; negative regulation of transcription, DNA-dependent; rhythmic process; transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9C0C6 |
| NCBI GenInfo Identifier: | 32307175 |
| NCBI Gene ID: | 85457 |
| NCBI Accession: | NP_219494.2 |
| UniProt Secondary Accession: | Q9C0C6,Q8N389, Q8NDZ1, B2RCI1 |
| UniProt Related Accession: | Q9C0C6 |
| Molecular Weight: | 42,692 Da |
| NCBI Full Name: | CLOCK-interacting pacemaker |
| NCBI Synonym Full Names: | CLOCK-interacting pacemaker |
| NCBI Official Symbol: | CIPC |
| NCBI Official Synonym Symbols: | KIAA1737 |
| NCBI Protein Information: | CLOCK-interacting pacemaker |
| UniProt Protein Name: | CLOCK-interacting pacemaker |
| UniProt Synonym Protein Names: | CLOCK-interacting circadian protein |
| Protein Family: | CLOCK-interacting pacemaker |
| UniProt Gene Name: | CIPC |
| UniProt Entry Name: | CIPC_HUMAN |
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