CIART Antibody (PACO39638)
- SKU:
- PACO39638
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CIART Antibody (PACO39638) |
| Antibody SKU: | PACO39638 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Circadian-associated transcriptional repressor protein (1-385AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO39638 at dilution of 1:100. |
| Background: | Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). |
| Synonyms: | Circadian-associated transcriptional repressor (ChIP-derived repressor of network oscillator) (Chrono) (Computationally highlighted repressor of the network oscillator), CIART, C1orf51 |
| UniProt Protein Function: | CHRONO: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factorChromosomal Location of Human Ortholog: 1q21.2Cellular Component: nucleusMolecular Function: protein bindingBiological Process: circadian regulation of gene expression; locomotor rhythm; negative regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N365 |
| NCBI GenInfo Identifier: | 21389605 |
| NCBI Gene ID: | 148523 |
| NCBI Accession: | NP_653298.1 |
| UniProt Secondary Accession: | Q8N365,Q8N795, Q96MG6, B2RD43, D3DV01 |
| UniProt Related Accession: | Q8N365 |
| Molecular Weight: | 12,982 Da |
| NCBI Full Name: | circadian-associated transcriptional repressor isoform a |
| NCBI Synonym Full Names: | circadian associated repressor of transcription |
| NCBI Official Symbol: | CIART |
| NCBI Official Synonym Symbols: | GM129; CHRONO; C1orf51 |
| NCBI Protein Information: | circadian-associated transcriptional repressor |
| UniProt Protein Name: | Circadian-associated transcriptional repressor |
| UniProt Synonym Protein Names: | ChIP-derived repressor of network oscillator; Chrono; Computationally highlighted repressor of the network oscillator |
| Protein Family: | Circadian-associated transcriptional repressor |
| UniProt Gene Name: | CIART |
| UniProt Entry Name: | CIART_HUMAN |
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