CIAO3 Antibody (PACO40582)
- SKU:
- PACO40582
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CIAO3 Antibody (PACO40582) |
| Antibody SKU: | PACO40582 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cytosolic iron-sulfur assembly component 3 protein (2-265AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: A549 whole cell lysate. All lanes: CIAO3 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 54, 27, 43 kDa. Observed band size: 54, 27 kDa. |
 | Immunofluorescent analysis of U251 cells using PACO40582 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO40582 at dilution of 1:100. |
| Background: | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. |
| Synonyms: | Cytosolic iron-sulfur assembly component 3, Cytosolic Fe-S cluster assembly factor NARFL (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf), CIAO3, NARFL, PRN |
| UniProt Protein Function: | NARFL: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. Belongs to the NARF family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 16p13.3 Biological Process: iron-sulfur cluster assembly; oxygen homeostasis; regulation of transcription, DNA-dependent; response to hypoxia |
| UniProt Code: | Q9H6Q4 |
| NCBI GenInfo Identifier: | 74733617 |
| NCBI Gene ID: | 64428 |
| NCBI Accession: | Q9H6Q4.1 |
| UniProt Secondary Accession: | Q9H6Q4,Q53GC6, Q96S10, Q9H6J8, A1L385, B3KTJ3, |
| UniProt Related Accession: | Q9H6Q4 |
| Molecular Weight: | 42,010 Da |
| NCBI Full Name: | Cytosolic Fe-S cluster assembly factor NARFL |
| NCBI Synonym Full Names: | nuclear prelamin A recognition factor like |
| NCBI Official Symbol: | NARFL |
| NCBI Official Synonym Symbols: | PRN; HPRN; IOP1; NAR1; LET1L |
| NCBI Protein Information: | cytosolic Fe-S cluster assembly factor NARFL |
| UniProt Protein Name: | Cytosolic Fe-S cluster assembly factor NARFL |
| UniProt Synonym Protein Names: | Iron-only hydrogenase-like protein 1; IOP1; Nuclear prelamin A recognition factor-like protein; Protein related to Narf |
| Protein Family: | Cytosolic Fe-S cluster assembly factor |
| UniProt Gene Name: | NARFL |
| UniProt Entry Name: | NARFL_HUMAN |
| Antibodies |
| NARFL Antibody (PACO01138) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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