CHTOP Antibody (PACO47254)
- SKU:
- PACO47254
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CHTOP Antibody (PACO47254) |
| Antibody SKU: | PACO47254 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Chromatin target of PRMT1 protein (179-248AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CHTOP antibody at 14 µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 27, 22 kDa. Observed band size: 27, 52 kDa.. |
 | Immunohistochemistry of paraffin-embedded human glioma using PACO47254 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO47254 at dilution of 1:100. |
| Background: | Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis. |
| Synonyms: | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG), CHTOP, C1orf77 FOP |
| UniProt Protein Function: | CHTOP: Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. 3 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-binding; NucleolusChromosomal Location of Human Ortholog: 1q21.3Cellular Component: intracellular membrane-bound organelle; nuclear speck; nucleoplasmMolecular Function: methyl-CpG binding; protein bindingBiological Process: mRNA 3'-end processing; mRNA export from nucleus; positive regulation of ATPase activity; positive regulation of cell proliferation; positive regulation of helicase activity; positive regulation of histone methylation; RNA export from nucleus; termination of RNA polymerase II transcription |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9Y3Y2 |
| NCBI GenInfo Identifier: | 331028739 |
| NCBI Gene ID: | 26097 |
| NCBI Accession: | NP_001193541.1 |
| UniProt Secondary Accession: | Q9Y3Y2,Q0VAQ8, Q2VPI9, Q5T7Y8, Q5T7Y9, Q5T7Z0, Q6NSM4 Q6PB28, Q8WYT9, Q9BUC5 |
| UniProt Related Accession: | Q9Y3Y2 |
| Molecular Weight: | 21,918 Da |
| NCBI Full Name: | chromatin target of PRMT1 protein isoform 2 |
| NCBI Synonym Full Names: | chromatin target of PRMT1 |
| NCBI Official Symbol: | CHTOP |
| NCBI Official Synonym Symbols: | FOP; SRAG; SRAG-3; SRAG-5; pp7704; C1orf77; FL-SRAG |
| NCBI Protein Information: | chromatin target of PRMT1 protein |
| UniProt Protein Name: | Chromatin target of PRMT1 protein |
| UniProt Synonym Protein Names: | Friend of PRMT1 protein; Small arginine- and glycine-rich protein; SRAG |
| Protein Family: | Chromatin target of PRMT1 protein |
| UniProt Gene Name: | CHTOP |
| UniProt Entry Name: | CHTOP_HUMAN |
| Antibodies |
| CHTOP Antibody (PACO08094) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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