CHST8 Antibody (PACO05031)
- SKU:
- PACO05031
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CHST8 Antibody (PACO05031) |
| Antibody SKU: | PACO05031 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human GalNAc4ST-1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CHST8; Carbohydrate sulfotransferase 8; GalNAc-4-O-sulfotransferase 1; GalNAc-4-ST1; GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1 |
| UniProt Protein Function: | CHST8: Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. CHST8 mutations may be a cause of generalized non- inflammatory peeling skin syndrome type A (PubMed:22289416). Peeling skin syndrome (PSS) is a genodermatosis characterized by continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. Belongs to the sulfotransferase 2 family.Protein type: Transferase; EC 2.8.2.-; Membrane protein, integralChromosomal Location of Human Ortholog: 19q13.1Cellular Component: Golgi membraneMolecular Function: N-acetylgalactosamine 4-O-sulfotransferase activityBiological Process: hormone biosynthetic process; proteoglycan biosynthetic process; sulfur metabolic processDisease: Peeling Skin Syndrome 3 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9H2A9 |
| NCBI GenInfo Identifier: | 61212124 |
| NCBI Gene ID: | 64377 |
| NCBI Accession: | Q9H2A9.2 |
| UniProt Secondary Accession: | Q9H2A9,Q9H3N2 |
| UniProt Related Accession: | Q9H2A9 |
| Molecular Weight: | 48,834 Da |
| NCBI Full Name: | Carbohydrate sulfotransferase 8 |
| NCBI Synonym Full Names: | carbohydrate sulfotransferase 8 |
| NCBI Official Symbol: | CHST8 |
| NCBI Official Synonym Symbols: | PSS3; GalNAc4ST; GALNAC4ST1 |
| NCBI Protein Information: | carbohydrate sulfotransferase 8 |
| UniProt Protein Name: | Carbohydrate sulfotransferase 8 |
| UniProt Synonym Protein Names: | GalNAc-4-O-sulfotransferase 1; GalNAc-4-ST1; GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1 |
| Protein Family: | Carbohydrate sulfotransferase |
| UniProt Gene Name: | CHST8 |
| UniProt Entry Name: | CHST8_HUMAN |
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