CHRDL2 Antibody (PACO19470)
- SKU:
- PACO19470
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CHRDL2 Antibody (PACO19470) |
| Antibody SKU: | PACO19470 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human CHRDL2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19470(CHRDL2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19470(CHRDL2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid, protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis. |
| Synonyms: | chordin-like 2 |
| UniProt Protein Function: | CHRDL2: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation. Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 11q14Cellular Component: extracellular space; cytoplasmBiological Process: ossification; cartilage development; cell differentiation; negative regulation of BMP signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q6WN34 |
| NCBI GenInfo Identifier: | 510937050 |
| NCBI Gene ID: | 25884 |
| NCBI Accession: | NP_001265402.1 |
| UniProt Secondary Accession: | Q6WN34 |
| UniProt Related Accession: | Q6WN34 |
| Molecular Weight: | |
| NCBI Full Name: | chordin-like protein 2 isoform 2 |
| NCBI Synonym Full Names: | chordin like 2 |
| NCBI Official Symbol: | CHRDL2 |
| NCBI Official Synonym Symbols: | BNF1; CHL2 |
| NCBI Protein Information: | chordin-like protein 2 |
| UniProt Protein Name: | Chordin-like protein 2 |
| UniProt Synonym Protein Names: | Breast tumor novel factor 1; BNF-1; Chordin-related protein 2 |
| Protein Family: | |
| UniProt Gene Name: | CHRDL2 |
| UniProt Entry Name: | CRDL2_HUMAN |
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