CHML Antibody (PACO23470)
- SKU:
- PACO23470
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CHML Antibody (PACO23470) |
| Antibody SKU: | PACO23470 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human CHML. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO cells, using CHML antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CHML antibody. |
| Background: | Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. |
| Synonyms: | Rab proteins geranylgeranyltransferase component A 2; Rab escort protein 2; REP-2; Choroideraemia-like protein; |
| UniProt Protein Function: | CHML: Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family. Belongs to the Rab GDI family.Chromosomal Location of Human Ortholog: 1q43Cellular Component: cytoplasm; nucleoplasm; Rab-protein geranylgeranyltransferase complexMolecular Function: Rab GTPase bindingBiological Process: protein geranylgeranylation |
| UniProt Protein Details: | |
| NCBI Summary: | The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26374 |
| NCBI GenInfo Identifier: | 47117837 |
| NCBI Gene ID: | 1122 |
| NCBI Accession: | P26374.2 |
| UniProt Secondary Accession: | P26374,Q17RE0, Q9H1Y4, B2RAB9 |
| UniProt Related Accession: | P26374 |
| Molecular Weight: | 74,071 Da |
| NCBI Full Name: | Rab proteins geranylgeranyltransferase component A 2 |
| NCBI Synonym Full Names: | CHM like, Rab escort protein 2 |
| NCBI Official Symbol: | CHML |
| NCBI Official Synonym Symbols: | REP2 |
| NCBI Protein Information: | rab proteins geranylgeranyltransferase component A 2 |
| UniProt Protein Name: | Rab proteins geranylgeranyltransferase component A 2 |
| UniProt Synonym Protein Names: | Choroideremia-like protein; Rab escort protein 2; REP-2 |
| Protein Family: | Rab proteins geranylgeranyltransferase component |
| UniProt Gene Name: | CHML |
| UniProt Entry Name: | RAE2_HUMAN |
| Antibodies |
| CHML Antibody (PACO01418) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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