Chk1 Polyclonal Antibody
- SKU:
- CAB21348
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Chk1 Polyclonal Antibody |
| Product Code: | CAB21348 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | A-431, 293T |
| Cellular Location: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 148-307 of Chk1 (NP_001265.2). |
| Sequence: | DFGLA TVFRY NNRER LLNKM CGTLP YVAPE LLKRR EFHAE PVDVW SCGIV LTAML AGELP WDQPS DSCQE YSDWK EKKTY LNPWK KIDSA PLALL HKILV ENPSA RITIP DIKKD RWYNK PLKKG AKRPR VTSGG VSESP SGFSK HIQSN LDFSP VNSAS |
| Synonyms: | CHK1 |
| Calculated MW: | 54kDa |
| Observed MW: | 44kDa |
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