Chk1 Monoclonal Antibody
- SKU:
- CAB22055
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Chk1 Monoclonal Antibody |
| Product Code: | CAB22055 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52506 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:10000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | K-562 |
| Cellular Location: | centrosome, condensed nuclear chromosome, cytoplasm, cytosol, extracellular space, nucleoplasm, nucleus |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Chk1 (NP_001107593.1). |
| Sequence: | PSARI TIPDI KKDRW YNKPL KKGAK RPRVT SGGVS ESPSG FSKHI QSNLD FSPVN SASSE ENVKY SSSQP EPRTG LSLWD TSPSY IDKLV QGISF SQPTC P |
| Synonyms: | CHK1 |
| Calculated MW: | 54kDa |
| Observed MW: | 56kDa |
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