CH25H Antibody (PACO51418)
- SKU:
- PACO51418
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CH25H Antibody (PACO51418) |
| Antibody SKU: | PACO51418 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cholesterol 25-hydroxylase protein (142-272AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO51418 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO51418 at dilution of 1:100. |
| Background: | Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. |
| Synonyms: | Cholesterol 25-hydroxylase (EC 1.14.99.38) (Cholesterol 25-monooxygenase) (h25OH), CH25H |
| UniProt Protein Function: | Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. |
| UniProt Protein Details: | |
| NCBI Summary: | This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95992 |
| NCBI GenInfo Identifier: | 4502499 |
| NCBI Gene ID: | 9023 |
| NCBI Accession: | NP_003947 |
| UniProt Secondary Accession: | O95992 |
| UniProt Related Accession: | O95992 |
| Molecular Weight: | 32kDa |
| NCBI Full Name: | cholesterol 25-hydroxylase |
| NCBI Synonym Full Names: | cholesterol 25-hydroxylase |
| NCBI Official Symbol: | CH25H |
| NCBI Official Synonym Symbols: | C25H |
| NCBI Protein Information: | cholesterol 25-hydroxylase |
| UniProt Protein Name: | Cholesterol 25-hydroxylase |
| UniProt Synonym Protein Names: | Cholesterol 25-monooxygenase; h25OH |
| Protein Family: | Cholesterol 25-hydroxylase |
| UniProt Gene Name: | CH25H |
| UniProt Entry Name: |
Related Products
Ch25h Polyclonal Antibody (CAB24299)
OverviewProduct Name:Ch25h Polyclonal AntibodyProduct Code:CAB24299Reactivity:MouseApplications:Western blotting
Human CH25H (Cholesterol 25-hydroxylase) ELISA Kit (HUFI03478)
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीकी
SPEF2 Antibody
Overview Product Name:SPEF2 AntibodyProduct Code:PACO64977Size:50µLTarget Names:SPEF2Species Reactivity:HumanHos