CGNL1 Antibody (PACO08387)
- SKU:
- PACO08387
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CGNL1 Antibody (PACO08387) |
| Antibody SKU: | PACO08387 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human CGNL1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | cingulin-like 1;CGNL1;FLJ14957;JACOP;KIAA1749;MGC138254 ; |
| UniProt Protein Function: | CGNL1: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Defects in CGNL1 are a cause of aromatase excess syndrome (AEXS). A disorder characterized by an estrogen excess due to an increased aromatase activity. A chromosomal aberration inv(15)(q21.2;q21.3) has been found in patients with aromatase excess syndrome. The inversion moves the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region. Belongs to the cingulin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesionChromosomal Location of Human Ortholog: 15q21.3 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q0VF96 |
| NCBI GenInfo Identifier: | 332278171 |
| NCBI Gene ID: | 84952 |
| NCBI Accession: | Q0VF96.2 |
| UniProt Secondary Accession: | Q0VF96,Q05BZ4, Q52LR0, Q695C7, Q7Z2L3, Q96JV2, Q96MN6 Q9C0B4 |
| UniProt Related Accession: | Q0VF96 |
| Molecular Weight: | 72,186 Da |
| NCBI Full Name: | Cingulin-like protein 1 |
| NCBI Synonym Full Names: | cingulin like 1 |
| NCBI Official Symbol: | CGNL1 |
| NCBI Official Synonym Symbols: | JACOP; PCING |
| NCBI Protein Information: | cingulin-like protein 1 |
| UniProt Protein Name: | Cingulin-like protein 1 |
| UniProt Synonym Protein Names: | Junction-associated coiled-coil protein; Paracingulin |
| Protein Family: | Cingulin-like protein |
| UniProt Gene Name: | CGNL1 |
| UniProt Entry Name: | CGNL1_HUMAN |
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