Description
Antibody Name: | CFHR2 Antibody (PACO33384) |
Antibody SKU: | PACO33384 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Complement factor H-related protein 2 protein (20-269AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: CFHR2 antibody at 2µg/ml Lane 1: Hela whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31, 28 kDa Observed band size: 36 kDa . | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO33384 at dilution of 1:100. |
Background: | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. |
Synonyms: | Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2), CFHR2, CFHL2 FHR2 HFL3 |
UniProt Protein Function: | CFHR2: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q31.3 Cellular Component: extracellular region |
NCBI Summary: | This gene belongs to a family of complement factor H-related genes (CFHR), which are clustered together with complement factor H gene on chromosome 1, and are involved in regulation of complement. Mutations in CFHR genes have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015] |
UniProt Code: | P36980 |
NCBI GenInfo Identifier: | 916404479 |
NCBI Gene ID: | 3080 |
NCBI Accession: | NP_001299601.1 |
UniProt Secondary Accession: | P36980,Q14310, Q5T9T1, |
UniProt Related Accession: | P36980 |
Molecular Weight: | |
NCBI Full Name: | complement factor H-related protein 2 isoform 2 |
NCBI Synonym Full Names: | complement factor H related 2 |
NCBI Official Symbol: | CFHR2 |
NCBI Official Synonym Symbols: | FHR2; HFL3; CFHL2 |
NCBI Protein Information: | complement factor H-related protein 2 |
UniProt Protein Name: | Complement factor H-related protein 2 |
UniProt Synonym Protein Names: | DDESK59; H factor-like 3; H factor-like protein 2 |
Protein Family: | Complement factor H-related protein |
UniProt Gene Name: | CFHR2 |
UniProt Entry Name: | FHR2_HUMAN |