CERS4 Antibody (PACO19927)
- SKU:
- PACO19927
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CERS4 Antibody (PACO19927) |
| Antibody SKU: | PACO19927 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human CERS4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19927(CERS4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19927(CERS4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid, endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis. |
| Synonyms: | ceramide synthase 4 |
| UniProt Protein Function: | Lass4: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.Protein type: Membrane protein, multi-pass; Membrane protein, integral; DNA-bindingChromosomal Location of Human Ortholog: 19p13.2Cellular Component: endoplasmic reticulum; endoplasmic reticulum membraneMolecular Function: sphingosine N-acyltransferase activityBiological Process: ceramide biosynthetic process; sphingolipid biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9HA82 |
| NCBI GenInfo Identifier: | 296434561 |
| NCBI Gene ID: | 79603 |
| NCBI Accession: | Q9HA82.2 |
| UniProt Secondary Accession: | Q9HA82,D6W665 |
| UniProt Related Accession: | Q9HA82 |
| Molecular Weight: | 46,399 Da |
| NCBI Full Name: | Ceramide synthase 4 |
| NCBI Synonym Full Names: | ceramide synthase 4 |
| NCBI Official Symbol: | CERS4 |
| NCBI Official Synonym Symbols: | Trh1; LASS4 |
| NCBI Protein Information: | ceramide synthase 4 |
| UniProt Protein Name: | Ceramide synthase 4 |
| UniProt Synonym Protein Names: | LAG1 longevity assurance homolog 4 |
| Protein Family: | Ceramide synthase |
| UniProt Gene Name: | CERS4 |
| UniProt Entry Name: | CERS4_HUMAN |
| Antibodies |
| CERS4 Antibody (PACO01014) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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