Description
Antibody Name: | CERS3 Antibody (PACO19925) |
Antibody SKU: | PACO19925 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human CERS3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cells, Primary antibody: PACO19925(CERS3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
Background: | LASS3 is a 383 amino acid, membrane protein almost exclusively expressed in testis, suggesting that LASS3 plays an important role in proper testis function. It is also weakly expressed in skin. A transcriptional variant of LASS3 cDNA exists and can result in the production of a 419 amino acid, protein (LASS3-long). LASS3 overproduction raises the level of several ceramide species, including C18:0- and C24:0-ceramides. |
Synonyms: | ceramide synthase 3 |
UniProt Protein Function: | Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation. |
UniProt Protein Details: | |
NCBI Summary: | This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
UniProt Code: | Q8IU89 |
NCBI GenInfo Identifier: | 594140617 |
NCBI Gene ID: | 204219 |
NCBI Accession: | NP_001277270.1 |
UniProt Secondary Accession: | Q8IU89,Q8NE64, Q8NEN6 |
UniProt Related Accession: | Q8IU89 |
Molecular Weight: | 46,316 Da |
NCBI Full Name: | ceramide synthase 3 isoform 1 |
NCBI Synonym Full Names: | ceramide synthase 3 |
NCBI Official Symbol: | CERS3 |
NCBI Official Synonym Symbols: | ARCI9; LASS3 |
NCBI Protein Information: | ceramide synthase 3 |
UniProt Protein Name: | Ceramide synthase 3 |
UniProt Synonym Protein Names: | Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3 |
Protein Family: | Ceramide synthase |
UniProt Gene Name: | CERS3 |
UniProt Entry Name: |