CEP152 Antibody (PACO22251)
- SKU:
- PACO22251
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CEP152 Antibody (PACO22251) |
| Antibody SKU: | PACO22251 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human CEP152. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human lymph node tissue using CEP152 antibody. |
| Background: | Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles. |
| Synonyms: | centrosomal protein 152 kDa; centrosomal protein 152kDa; centrosomal protein of 152 kDa; |
| UniProt Protein Function: | Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010] |
| UniProt Code: | O94986 |
| NCBI GenInfo Identifier: | 303304991 |
| NCBI Gene ID: | 22995 |
| NCBI Accession: | NP_001181927.1 |
| UniProt Secondary Accession: | O94986,Q17RV1, Q6NTA0, E7ER66 |
| UniProt Related Accession: | O94986 |
| Molecular Weight: | 189,071 Da |
| NCBI Full Name: | centrosomal protein of 152 kDa isoform 1 |
| NCBI Synonym Full Names: | centrosomal protein 152kDa |
| NCBI Official Symbol: | CEP152 |
| NCBI Official Synonym Symbols: | MCPH4; MCPH9; SCKL5 |
| NCBI Protein Information: | centrosomal protein of 152 kDa |
| UniProt Protein Name: | Centrosomal protein of 152 kDa |
| UniProt Synonym Protein Names: | |
| Protein Family: | Centrosomal protein |
| UniProt Gene Name: | CEP152 |
| UniProt Entry Name: | CE152_HUMAN |
| Antibodies |
| CEP152 Antibody (PACO02742) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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