CEP152 Antibody (PACO02742)
- SKU:
- PACO02742
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CEP152 Antibody |
| Antibody SKU: | PACO02742 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human CEP152. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CEP152; KIAA0912; Centrosomal protein of 152 kDa; Cep152 |
| UniProt Protein Function: | Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010] |
| UniProt Code: | O94986 |
| NCBI GenInfo Identifier: | 303304991 |
| NCBI Gene ID: | 22995 |
| NCBI Accession: | NP_001181927.1 |
| UniProt Secondary Accession: | O94986,Q17RV1, Q6NTA0, E7ER66 |
| UniProt Related Accession: | O94986 |
| Molecular Weight: | 189,071 Da |
| NCBI Full Name: | centrosomal protein of 152 kDa isoform 1 |
| NCBI Synonym Full Names: | centrosomal protein 152kDa |
| NCBI Official Symbol: | CEP152 |
| NCBI Official Synonym Symbols: | MCPH4; MCPH9; SCKL5 |
| NCBI Protein Information: | centrosomal protein of 152 kDa |
| UniProt Protein Name: | Centrosomal protein of 152 kDa |
| UniProt Synonym Protein Names: | |
| Protein Family: | Centrosomal protein |
| UniProt Gene Name: | CEP152 |
| UniProt Entry Name: | CE152_HUMAN |
Related Products
HS3ST3B1 Antibody
Overview Product Name:HS3ST3B1 AntibodyProduct Code:PACO64781Size:50µLTarget Names:HS3ST3B1Species Reactivity:Human<
hns Antibody
Overview Product Name:hns AntibodyProduct Code:PACO64777Size:50µLTarget Names:hnsSpecies Reactivity:Escherichia coli
Avpr1b Antibody
Overview Product Name:Avpr1b AntibodyProduct Code:PACO64609Size:50µLTarget Names:Avpr1bSpecies Reactivity:RatHos
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost