CENPV Antibody (PACO20281)
- SKU:
- PACO20281
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CENPV Antibody (PACO20281) |
| Antibody SKU: | PACO20281 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human CENPV |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20281(CENPV Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane 1-4: Raji cells, Jurkat cells, 293T cells, hela cells, Primary antibody: PACO20281(CENPV Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20281(CENPV Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | CENPV orthologs were detected in a range of species, including plants, but the proline-rich region was detected only in primates, rodents, birds, and amphibians, and long proline stretches were found only in primates. Northern blot analysis showed ubiquitous Cenpv expression in mouse tissues, with highest expression in testis, followed by small intestine, brain, and kidney. Immunofluorescence microscopy of mouse fibroblasts revealed colocalization of Cenpv with stabilized cytoplasmic microtubules. Western blot analysis of Ramos B cells detectedCENPV at an apparent molecular mass of 40 kD. |
| Synonyms: | centromere protein V |
| UniProt Protein Function: | CENPV: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. Belongs to the gfa family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17p11.2Cellular Component: microtubule cytoskeleton; kinetochore; nucleoplasm; cytoplasm; spindle midzone; nucleusMolecular Function: carbon-sulfur lyase activityBiological Process: positive regulation of cytokinesis; mitosis; cell division; metabolic process; ameboidal cell migration; centric heterochromatin formation; regulation of chromosome organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7Z7K6 |
| NCBI GenInfo Identifier: | 30851214 |
| NCBI Gene ID: | 201161 |
| NCBI Accession: | NP_859067 |
| UniProt Secondary Accession: | Q7Z7K6,Q3L8N5, Q8NFH6, B2RPK2 |
| UniProt Related Accession: | Q7Z7K6 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | CENPV protein |
| NCBI Synonym Full Names: | centromere protein V |
| NCBI Official Symbol: | CENPV |
| NCBI Official Synonym Symbols: | p30; PRR6; CENP-V; 3110013H01Rik |
| NCBI Protein Information: | centromere protein V; nuclear protein p30; proline rich 6; proline-rich protein 6 |
| UniProt Protein Name: | Centromere protein V |
| UniProt Synonym Protein Names: | Nuclear protein p30; Proline-rich protein 6 |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | CENPV |
| UniProt Entry Name: | CENPV_HUMAN |
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