CENPM Antibody (PACO16010)
- SKU:
- PACO16010
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CENPM Antibody (PACO16010) |
| Antibody SKU: | PACO16010 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Full length fusion protein |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16010(CENPM Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16010(CENPM Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]). |
| Synonyms: | centromere protein M |
| UniProt Protein Function: | CENPM: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 22q13.2Cellular Component: nucleoplasm; cytosolBiological Process: nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NSP4 |
| NCBI GenInfo Identifier: | 47117330 |
| NCBI Gene ID: | 79019 |
| NCBI Accession: | Q9NSP4.1 |
| UniProt Secondary Accession: | Q9NSP4,Q6I9W3, A7LM22, B1AHQ9 |
| UniProt Related Accession: | Q9NSP4 |
| Molecular Weight: | 11,687 Da |
| NCBI Full Name: | Centromere protein M |
| NCBI Synonym Full Names: | centromere protein M |
| NCBI Official Symbol: | CENPM |
| NCBI Official Synonym Symbols: | PANE1; CENP-M; C22orf18; bK250D10.2 |
| NCBI Protein Information: | centromere protein M; interphase centromere complex protein 39; proliferation associated nuclear element 1; proliferation-associated nuclear element protein 1 |
| UniProt Protein Name: | Centromere protein M |
| UniProt Synonym Protein Names: | Interphase centromere complex protein 39; Proliferation-associated nuclear element protein 1 |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | CENPM |
| UniProt Entry Name: | CENPM_HUMAN |
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