Description
| Product Name: | CDKN2C/p18-INK4C Polyclonal Antibody |
| Product Code: | CAB21326 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | cytoplasm, cytosol, nucleus |
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C/p18-INK4C (NP_523240.1). |
| Sequence: | MAEPW GNELA SAAAR GDLEQ LTSLL QNNVN VNAQN GFGRT ALQVM KLGNP EIARR LLLRG ANPDL KDRTG FAVIH DAARA GFLDT LQTLL EFQAD VNIED NEGNL PLHLA AKEGH LRVVE FLVKH TASNV GHRNH KGDTA CDLAR LYGRN EVVSL MQANG AGGAT NLQ |
| Synonyms: | p18, INK4C, p18-INK4C |
| Calculated MW: | 18kDa |
| Observed MW: | Refer to figures |
![Anti-CDKN2C/p18-INK4C Antibody (CAB18054)[KO Validated]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/55198/59941/anti-cdkn2cp18-ink4c-antibody-cab18054ko-validated__45061__60290.1706529197.jpg?c=1 "Anti-CDKN2C/p18-INK4C Antibody (CAB18054)[KO Validated]")
